Background: There is a significant discourse in the literature that opines that people who use illicit opiates are unable to provide informed consent due to withdrawal symptoms and cognitive impairment as a result of opiate use. Aims: This paper discusses the issues related to informed consent for this population. Ethical considerations: Ethical approval was obtained from both the local REB and the university. Written informed consent was obtained from all participants. Method: This was a qualitative interpretive descriptive study. 22 participants (...) were interviewed, including 18 nurses, 2 social workers and 2 clinic support workers. The findings were analyzed using thematic analysis, which is a way of systematically reducing the complexity of the information to arrive at generalized explanations. Results: The staff at the clinic were overwhelming clear in their judgment that people who use opiates can and should be able to participate in research and that their drug use is not a barrier to informed consent. Conclusions: It is important to involve people who use opiates in research. Protectionist concerns about this population may be overstated. Such concerns do not promote the interests of research participants. People who use heroin need to be able to tell their story. (shrink)

We have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate (...) assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)

Due to the ethical breaches of tobacco companies over a 50-year period, a U.S. Court ruled in United States v. Philip Morris USA, Inc. that major U.S. tobacco companies had misled consumers and the government about tobacco’s addictiveness, effects of environmental smoke, marketing targeted at adolescents, and deceptive practices related to harmfulness of smoking. We address the actions of the tobacco companies based on the consumer’s right to be informed and values for ethical corporate behavior, and we draw from psychological (...) theories and the smoking literature to develop our conceptual framework and test the effectiveness of the ensuing corrective advertising campaign mandated in the Court decision. We use a quota sample of 470 smokers and non-smoker participants in a longitudinal study to test the impact of the corrective advertising campaign on key antismoking beliefs from the campaign. Results reveal that the corrective ad campaign has not been successful in affecting smokers’ or non-smokers’ antismoking beliefs. However, differences are found between smokers’ and non-smokers’ beliefs about the adverse health effects of smoking, effects of secondhand smoke, and tobacco company deceptiveness, with these beliefs being stronger for non-smokers. Smokers’ weaker beliefs about the effects of secondhand smoke are viewed as particularly problematic, given the established health risks. We address the implications of the ethical breaches and the corrective advertising attempt to address the deception identified by the Court. (shrink)

Evidence-accumulation models (EAMs) are powerful tools for making sense of human and animal decision-making behavior. EAMs have generated significant theoretical advances in psychology, behavioral economics, and cognitive neuroscience and are increasingly used as a measurement tool in clinical research and other applied settings. Obtaining valid and reliable inferences from EAMs depends on knowing how to establish a close match between model assumptions and features of the task/data to which the model is applied. However, this knowledge is rarely articulated in the (...) EAM literature, leaving beginners to rely on the private advice of mentors and colleagues and inefficient trial-and-error learning. In this article, we provide practical guidance for designing tasks appropriate for EAMs, relating experimental manipulations to EAM parameters, planning appropriate sample sizes, and preparing data and conducting an EAM analysis. Our advice is based on prior methodological studies and the our substantial collective experience with EAMs. By encouraging good task-design practices and warning of potential pitfalls, we hope to improve the quality and trustworthiness of future EAM research and applications. (shrink)

We use the case of red meat food safety to illustrate the need to problematize policy. Overtime, there have been numerous red meat scandals and scares. We show that the statutes and regulations that arose out of these events provided the industry with a means of demonstrating safety, facilitating large-scale trade, legitimizing conventional production, and limiting interference into its practices. They also created systemic fragility, as evidenced by many recent events, and hindered the development of an alternative, small-scale sector. Thus, (...) the accumulated rules help to structure the sector, create superficial resilience, and are used in place of an actual policy governing safety. We call for rigorous attention to not only food safety, but also the role and effect of agrifood statutes and regulations in general, and engagement in policy more broadly. (shrink)

[DOI: 10.1097/j.pain.0000000000000765] Amanda Williams and Kenneth Craig, in a recent article in the IASP official journal _Pain_ (DOI: 10.1097/j.pain.0000000000000613), have argued that it is time to revise the IASP's well-entrenched definition of 'pain'. They propose an alternative definition. We critically discuss their proposed revision and argue that it admits clear counterexamples as both sufficient and necessary conditions. We further discuss the wisdom of replacing 'unpleasant' in the IASP definition with 'distress' as Williams and Craig propose. [Craig and (...) Williams respond to our criticism in DOI: 10.1097/j.pain.0000000000000766]. (shrink)

Recent findings indicate that frontal brain asymmetry may be a marker of for depression. However, the psychological predispositions that account linkage between frontal brain asymmetry and depression are unclear. approach-withdrawal hypothesis is the primary framework that has been to account for the linkages between frontal brain asymmetry and or emotional disorders. We review evidence consistent with this and suggest several directions for its extension. One such direction is to constrain the approach-withdrawal hypothesis by linking frontal asymmetry to the known functions (...) of the prefrontal cortex. On this we propose that frontal brain asymmetry may be preferentially linked processes that promote the temporal continuity and shifting of or emotional priorities and the suppression of interference by sources of motivation or emotion. We review evidence from and neurobiological studies of depression that is broadly consistent with these predictions. We emphasise the need for future studies testing our hypotheses. (shrink)

Drawing on theoretical arguments from the psychology discipline, we investigate the implications of employee entitlement in organizational settings. Specifically, we utilize workplace engagement theory to suggest that due to their skewed sense of deservingness, employees high in entitlement are less likely to experience workplace engagement. Furthermore, the negative relationship between employee entitlement and workplace engagement is strengthened when ethical leadership is low, yet mitigated when ethical leadership is high. Finally, we predict that under conditions of low ethical leadership, reductions in (...) engagement explain why employee entitlement results in hindered job performance. This mediated effect does not hold when ethical leadership is high. We tested our theoretical model utilizing field data from employees and their direct supervisors in the financial services industry. Our results support our theoretical model. Theoretical and practical implications are discussed. (shrink)

This book updates and adds to the classic Social Movements of the Sixties and Seventies, showing how social movement theory has grown and changed.

This paper is a systematic exploration of non-wellfounded mereology. Motivations and applications suggested in the literature are considered. Some are exotic like Borges’ Aleph, and the Trinity; other examples are less so, like time traveling bricks, and even Geach’s Tibbles the Cat. The authors point out that the transitivity of non-wellfounded parthood is inconsistent with extensionality. A non-wellfounded mereology is developed with careful consideration paid to rival notions of supplementation and fusion. Two equivalent axiomatizations are given, and are compared to (...) classical mereology. We provide a class of models with respect to which the non-wellfounded mereology is sound and complete. (shrink)

Thirteen original essays by leading scholars explore aspects of Spinoza's ethical theory and, in doing so, deepen our understanding of it as the richly rewarding core of his system. They resolve interpretive difficulties, advance longstanding debates, and point the direction for future research.

Planetary degradation continues despite widely publicized eco-friendly behaviors of individual firms, creating a big disconnect. Drawing upon paradox theory, we examine the prevalence of both corporate compensatory action and environmental inaction after a firm commits environmental misdeeds. We argue that both limited compensatory actions and persistent inaction pose significant moral, economic, and system-level ecological implications. Next, based on insights from crisis management literature, we propose a multi-stage, sequential model to predict both the likelihood that a firm takes eco-friendly action after (...) misdeeds and, if it does, the extent of these actions. In the first stage, we hypothesize that firm size, a proxy for visibility, positively moderates the likelihood of taking eco-friendly action to redirect negative attention after misdeeds. In the second stage, we hypothesize that smaller, more nimble firms have an implementation advantage, leading to a higher likelihood of more action after misdeeds. Based on 12,012 observations from the KLD sample of US-based firms between 2013 and 2019, inclusive, we find support for the big disconnect, since we find that inaction is the most common response after misdeeds. We also find that larger firms are more likely to have eco-friendly behaviors. And, for those firms who take action, smaller firms undertake more compensatory actions after environmental misdeeds. Persistent inaction and dispersed, small-scale compensatory actions can be problematic. Smaller firms may expend unnecessary resources and not get credit for disparate, eco-friendly activities. At the same time, larger firms may get more credit than deserved despite relatively limited actions. Collectively, inaction and dispersed compensatory action may not have sufficient impact to alter ecological degradation with subsequent intergenerational, irreversible harms. Nuanced practical and scholarly implications that curtail limited action while encouraging small firm experimentation are explored. (shrink)

In order to improve our understanding of the components that reflect functionally important processes during reward anticipation and consumption, we used principle components analyses (PCA) to separate and quantify averaged ERP data obtained from each stage of a modified monetary incentive delay (MID) task. Although a small number of recent ERP studies have reported that reward and loss cues potentiate ERPs during anticipation, action preparation, and consummatory stages of reward processing, these findings are inconsistent due to temporal and spatial overlap (...) between the relevant electrophysiological components. Our results show three components following cue presentation are sensitive to incentive cues (N1, P3a, P3b). In contrast to previous research, reward‐related enhancement occurred only in the P3b, with earlier components more sensitive to break‐even and loss cues. During feedback anticipation, we observed a lateralized centroparietal negativity that was sensitive to response hand but not cue type. We also show that use of PCA on ERPs reflecting reward consumption successfully separates the reward positivity from the independently modulated feedback‐P3. Last, we observe for the first time a new reward consumption component: a late negativity distributed over the left frontal pole. This component appears to be sensitive to response hand, especially in the context of monetary gain. These results illustrate that the time course and sensitivities of electrophysiological activity that follows incentive cues do not follow a simple heuristic in which reward incentive cues produce enhanced activity at all stages and substages. (shrink)

This article describes the historical emergence of vital systems security, analyzing it as a significant mutation in biopolitical modernity. The story begins in the early 20th century, when planners and policy-makers recognized the increasing dependence of collective life on interlinked systems such as transportation, electricity, and water. Over the following decades, new security mechanisms were invented to mitigate the vulnerability of these vital systems. While these techniques were initially developed as part of Cold War preparedness for nuclear war, they eventually (...) migrated to domains beyond national security to address a range of anticipated emergencies, such as large-scale natural disasters, pandemic disease outbreaks, and disruptions of critical infrastructure. In these various contexts, vital systems security operates as a form of reflexive biopolitics, managing risks that have arisen as the result of modernization processes. This analysis sheds new light on current discussions of the government of emergency and ‘states of exception’. Vital systems security does not require recourse to extraordinary executive powers. Rather, as an anticipatory technology for mitigating vulnerabilities and closing gaps in preparedness, it provides a ready-to-hand toolkit for administering emergencies as a normal part of constitutional government. (shrink)

Facing an increasing number and variety of issues with social salience, firms must determine how to engage with issues that likely have a significant impact on them. Integrating issues management and salience theories, the authors find that firms engage with socially contested issues—where there is a high degree of societal disagreement—in a different manner from issues that have social consensus, or high agreement. Examining social issue resolutions filed by shareholders from 1997 to 2009, the study finds that socially contested issues, (...) as well as those issues with social consensus, are both likely to result in engagement by the firm. For social issues with consensus, a firm is more likely to opt for a low level of shareholder engagement whereas resolutions regarding contested issues lead to engaging shareholders at a higher level. These findings shed new light on the IM and issue salience literature streams that have suggested firms will react differently to these types of issues, even while they remain largely untested. Finally, firms become less engaged with perennial issues over time. rather than more, providing new guidance to researchers, shareholder activists, and firms alike. To the authors’ knowledge, such fined-grained insight into expected levels of firm engagement with social issue salience has not been put forth previously. (shrink)

Despite great advances in understanding genetic mechanisms, there still exists a bias toward equating genes with innate modules that determine important developmental events. But genes are equally relevant to understanding developmental plasticity shaped by ecological events. In other words, the term 'genetic inheritance' does not specify ontogenetic mechanisms. Here we present a case history of a species assumed to be under the control of prespecified genetic wiring to direct critical behavioral events such as communication and mating. We show, however, that (...) exogenetic processes stemming from the species's ontogenetic niche provide an alternative view of the flexibility of development especially with respect to behavioral performance. (shrink)

Spatial thought is undergoing somewhat of a renaissance in nursing. Building on a long disciplinary tradition of conceptualizing and studying ‘nursing environment’, the past twenty years has witnessing the establishment and refinement of explicitly geographical nursing research. This article – part one in a series of two – reviews the perspectives taken to date, ranging from historical precedent in classical nursing theory through to positivistic spatial science, political economy, and social constructivism in contemporary inquiry. This discussion sets up part two, (...) which considers the potential of non‐representational theory for framing future studies. (shrink)

Review of Causation and Free Will by Carolina Sartorio, Oxford University Press, 2016. viii + 188 pp. £35.00.

The classical Confucian philosopher Xunzi proposed a naturalistic virtue ethics account of ritual: rituals are practices that channel human emotion and desire so that one develops virtues. In this paper I show that William of Auxerre’s Summa de Officiis Ecclesiasticis can be understood as presenting a similar account of ritual. William places great emphasis on the emotional power of the liturgy, which makes participants like the blessed in heaven by developing virtue. In other words, he has a virtue ethics of (...) ritual closely aligned with that of Xunzi. Xunzi’s writings on ritual illuminate and enrich one’s reading of the Summa de Officiis. But unlike Xunzi, William is not a naturalist with regard to ritual: although much of William’s language about the causal power of liturgy can be explained in Xunzian terms, Christian liturgy has an irreducible supernatural element. (shrink)

In this outstanding reinterpretation - and extension - of the Critical Theory tradition, Craig Calhoun surveys the origins, fortunes and prospects of this most influential of theoretical approaches. Moving with ease from the early Frankfurt School to Habermas, to contemporary debates over postmodernism, feminism and nationalism, Calhoun breathes new life into Critical Social Theory, showing how it can learn from the past and contribute to the future.

Volume 20, Issue 3, March 2020, Page 35-37.

In 2018, William Lane Craig and Erik J. Wielenberg participated in a debate at North Carolina State University, addressing the question: "God and Morality: What is the best account of objective moral values and duties?" Craig argued that theism provides a sound foundation for objective morality whereas atheism does not. Wielenberg countered that morality can be objective even if there is no God. This book includes the full debate, as well as endnotes with extended discussions that were not (...) included in the debate. It also includes five chapters by other philosophers who have written substantive responses to the debate - J. P. Moreland, David Baggett, Mark Linville, Wes Morriston, and Michael Huemer. The book provides crucial resources for better understanding moral realism and its dependence on, or independence from, theistic foundations. Key Features A valuable debate about whether or not God is the best explanation for objective morality, bringing together theists and atheists working on the same subject who normally are not in conversation with each other. Includes clear coverage of ontological and epistemological issues in metaethical theories, focusing on Divine Command Theory and Non-natural Robust Moral Realism. Engaging and accessible throughout, making the book well suited for undergraduate and seminary classrooms. (shrink)

Part one in this two paper series reviewed the nature of geographical thinking in nursing research thus far. The current paper builds on it by looking forwards and providing a particular vision for future research. It argues that it is time to once again look to the parent discipline of human geography for inspiration, specifically to its turn towards non‐representational theory, involving an emphasis on life that onflows prior to meaning, significance, and full cognition; on life's ‘taking‐place’. The paper introduces (...) this way of viewing and animating the world. Some potential connections to nursing research and practice are suggested, as are some specific avenues for future inquiry. Explained is how, through non‐representational theory, nursing might be re‐imagined as something that reveals space‐time. (shrink)

_341_ _Objectives: _In patients with multivessel disease both the detection of the culprit lesion and the exact allocation are important preconditions for sufficient treatment and improved outcome. In a vessel based approach the combination of quantitative coronary angiography and fractional flow reserve measured by a pressure wire should be advantageous compared to myocardial SPECT, as morphological and functional information is delivered simultaneously. Therefore our aim was to evaluate MS in the detection and allocation of hemodynamically significant stenoses obtained by the (...) combined gold standard QCA plus FFR in patients with multivessel disease. _Methods: _FFR and QCA of 95 vessels in 80 patients have been evaluated. Hemodynamically significant target lesions were defined as intermediate stenoses between 50 and 75% with an FFR. (shrink)

This chapter explores how the immediacy and feeling of past times and places, and how they are important to health and wellbeing, might be conveyed through the humanities tradition of oral history. It reports on 17 oral history interviews conducted between 2005 and 2012 with senior residents of the town of Teignmouth, Devon, UK, who experienced the World War II coastal homefront first-hand, and in particular the numerous ‘tip and run’ air attacks that took place. The chapter focuses on how (...) respondents recollect events as sensory encounters. It argues that these encounters are important experiences on their own right, involving their own level and form of knowing time and place, but also in terms of how they interplay with meanings consciously attributed to them. Whilst encounters can re-emerge like ‘hauntings’ from the past in the process of respondents recalling and conveying, they might equally act like pre-emptive affective facts, helping researchers feel, empathise with and ultimately reanimate what it felt like to be there. (shrink)

Physiological studies of binocular rivalry have provided important clues to the relationship between neural activity in the brain and visual awareness.However, uncertainty about these insights has been raised by a recent study showing that the events underlying binocular rivalry occur earlier in the visual pathway than was previously thought.

This essay examines the implications Wikipedia holds for theories of deliberative democracy. It argues that while similar in some respects, the mode of interaction within Wikipedia represents a distinctive form of “collaborative editing” that departs from many of the qualities traditionally associated with face-to-face deliberation. This online mode of interaction overcomes many of the problems that distort face-to-face deliberations. By mitigating problems that arise in deliberative practice, such as “group polarization” and “hidden profiles,” the wiki model often realizes the epistemic (...) and procedural aspirations of deliberative democracy. These virtues of the Wikipedia model should not, however, lead to the simple conclusion that it ought to replace traditional face-to-face deliberation. Instead, this essay argues that the collaborative editing process found within Wikipedia ought to be viewed as a promising supplement to traditional deliberation. These two modes of communication ought to be viewed in Madisonian terms – as distinctive forms of interaction that check and balance the vices of one another. When combined, the wiki model promotes the virtues of inclusion and accuracy at large scales, while the face-to-face model excels in conditions of localism and promotes the virtues of solidarity and social capital. (shrink)

The central feature of modern liberal political morality is the principle of equal respect for persons. According to Ronald Dworkin, governments have an obligation to treat each person as an equal, with equal concern and respect. In distributive contexts, this principle stipulates that each individual is entitled to an “equal” share of social resources, where equal is a function of what is required by the abstract principle of equal concern and respect. For Dworkin, this requirement means that liberal justice is (...) fundamentally concerned with treating peopleas equalsand notequally. By treating someone as an equal he supposes that government must treat each of its citizens with equal dignity, regarding her as an individual with a standing interest in leading a truly good life. By contrast, to treat someone equally, according to Dworkin, “...requires that government treat all those in its chargeequallyin the distribution of some resource or opportunity....” To treat persons as equals, that is, with equal concern and respect, is to arrange for all individuals to receive those material goods and opportunities that make living a good life possible. For my purposes, I will assume that treating people as equals is the constitutive feature of liberal equality. (shrink)

Bringing children to have respect for others is generally regarded as a central task of moral and social education. In this article one particular view of what ‘respect for others’ means and how it is justified is examined critically and found to be unsatisfactory. This view states that ‘respect for others’ follows logically from the proper conceptualization of ‘person’, and claims, as a consequence, that in bringing children to respect others moral educators would be engaged primarily in a cognitive task (...) (ie helping children to acquire the proper concept of a ‘person') ‐‐ and would not have to resort to the conditioning of attitudes or the use of extrinsic motivation. This view is unsatisfactory, it is argued, as it does not give a correct account of the logical relationship between ‘person’ and ‘respect’ ‐‐ and the conclusion is drawn that it has not been shown that moral and social education can be primarily cognitive, in this particular respect. Neither has it been shown that conditioning of attitudes is unnecessary. (shrink)

Everyday reasoning requires more evidence than raw data alone can provide. We explore the idea that people can go beyond this data by reasoning about how the data was sampled. This idea is investigated through an examination of premise non‐monotonicity, in which adding premises to a category‐based argument weakens rather than strengthens it. Relevance theories explain this phenomenon in terms of people's sensitivity to the relationships among premise items. We show that a Bayesian model of category‐based induction taking premise sampling (...) assumptions and category similarity into account complements such theories and yields two important predictions: First, that sensitivity to premise relationships can be violated by inducing a weak sampling assumption; and second, that premise monotonicity should be restored as a result. We test these predictions with an experiment that manipulates people's assumptions in this regard, showing that people draw qualitatively different conclusions in each case. (shrink)

The concept of noman in Hagen encompasses a local theory of consciousness, agency, and morality. Interview materials are given to illustrate notions of how the noman works. The Hageners recognize a kind of duality between mind and body but no fundamental split between them. Their theory of consciousness is also a theory of morality and ethics, as well as a recognition of creative agency in life. Key words: Mount Hagen, person, gender, body/mind.